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Light-Triggered Release Of Bioactive Molecules From DNA Nanostructures

Shanghai Biopharmaleader Co.,Ltd | Updated: Nov 12, 2016

Light-Triggered Release of Bioactive Molecules from DNA Nanostructures

Recent innovations in DNA nanofabrication allow the creation of intricately shaped nanostructures ideally suited for many biological applications. To advance the use of DNA nanotechnology for the controlled release of bioactive molecules, we report a general strategy that uses light to liberate encapsulated cargoes from DNA nanostructures with high spatiotemporal precision. Through the incorporation of a custom, photolabile cross-linker, we encapsulated cargoes ranging in size from small molecules to full-sized proteins within DNA nanocages and then released such cargoes upon brief exposure to light. This novel molecular uncaging technique offers a general approach for precisely releasing a large variety of bioactive molecules, allowing investigation into their mechanism of action, or finely tuned delivery with high temporal precision for broad biomedical and materials applications.

Shanghai Biopharmaleader Co.,Ltd is a young and innovative company specializing in the design and synthesis of organic compounds for pharmaceutical, medicinal chemistry, biotechnology, drug discovery industries and world's top universities.

We specialize in complex, multi-stage custom synthesis and process research. We are capable of supplying mg to multiple-ton quantities of key pharmaceutical intermediates and APIs, pre-clinical and high-throughput screening compounds, analogues, building blocks.

More: Bioactive molecules

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