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Bioactive Molecules: Current Trends In Discovery, Synthesis, Delivery And Testing

Shanghai Biopharmaleader Co.,Ltd | Updated: Nov 12, 2016

Bioactive molecules: current trends in discovery, synthesis, delivery and testing

Important bioactive molecules are molecules that are pharmacologically active derived from natural sources and through chemical synthesis. Over the years many of such molecules have been discovered through bioprospective endeavours. The discovery of taxol from the paci c yew tree bark that has the ability in stabilising cellular microtubules represents one of the hallmarks of success of such endeavours. In recent years, the discovery process has been aided by the rapid development of techniques and technologies in chemistry and biotechnology. The progress in advanced genetics and computational biology has also transformed the way hypotheses are formulated as well as the strategies for drug discovery. Of equal importance is the use of advanced drug delivery vehicles in enhancing the ef cacy and bioavailability of bioactive molecules. The availability of suitable animal models for testing and validation is yet another major determinant in increasing the prospect for clinical trials of bioactive molecules.

The search for bioactive molecules has been an ongoing task as long as we believe 

molecules are the answers for various human ailments and diseases. The development in the  eld has seen numerous advancements both in its science as well as techniques and enabling technologies that have been driving the pace of discovery and synthesis. The recent progresses in bioinformatics, chemical genetics and computational biology have changed the way and direction in which bioactive molecules are classi ed and discovered. Advances in these areas together with combinatorial chemistry, have transformed the landscape of modern scienti c discovery of bioactive molecules, thus making their availability to consumers more certain. This review will brie y revisit the chemistry of what makes molecules biologically active. Thereafter, the currently advanced technology for the identi cation, detection, synthesis and delivery of pharmacologically active molecules will be discussed. Finally, an overview of a suitable and reliable animal model for the high throughput screening ofbioactive molecules is presented.

The Chemistry of Bioactive Molecules

The natural world is full of plant and other material resources in which bioactive molecules are obtained. Sources of these bioactive materials include from plant and animal sources, marine and also those that are semi- synthetically derived. 


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