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Resolution of a racemic pharmaceutical intermediate: A comparison of preparative HPLC, steady state recycling, and simulated moving bed

Shanghai Biopharmaleader Co.,Ltd | Updated: Feb 28, 2017

Preparative HPLC and simulated moving bed (SMB) chromatography were used to resolve significant quantities of a racemic pharmaceutical intermediate. In addition, smaller scale studies using closed-loop recycling and steady state recycling (SSR) were performed so that a meaningful comparison of all these techniques could be made using the same real world separation. A highly optimized, six-column SMB process was clearly the superior technique and was used for the process-scale (247 kg of racemate) resolution. At the more moderate lab-scale (33 kg of racemate and 19 kg of racemate), a frequently used but less optimized eight-column SMB process was used. It was found that SSR was comparable to the lab-scale SMB process in productivity and solvent consumption. Thus, it appears that SSR can be a useful choice at such moderate scales. Finally, at moderate scales when neither SSR nor SMB is available, it was found that acceptable results were obtained with both closed-loop recycling and with a two-step preparative process.

Shanghai Biopharmaleader Co.,Ltd is a young and innovative company specializing in the design and synthesis of organic compounds for pharmaceutical, medicinal chemistry, biotechnology, drug discovery industries and world's top universities.

We specialize in complex, multi-stage custom synthesis and process research. We are capable of supplying mg to multiple-ton quantities of key pharmaceutical intermediates and Bioactive Molecules, pre-clinical and high-throughput screening compounds, analogues, building blocks.

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