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Bioactive Molecules

Enasidenib CAS:1446502-11-9

Enasidenib CAS:1446502-11-9
CAS NO.1446502-11-9
Product Name Enasidenib
Molecular Weight473.14
Spec / Purity98%min
Supply Capacity
Details Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer . The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer.


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