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Bioactive Molecules

Ivosidenib CAS:1448347-49-6

Ivosidenib CAS:1448347-49-6

 

CAS NO.1448347-49-6
Product Name Ivosidenib
SynonymsAG-120; RG120
FormulaC28H22ClF3N6O3
Molecular Weight582.14
Spec / Purity98%min
Supply Capacity
Details Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.

 

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